The San Diego Padres (82-65) and San Francisco Giants (72-75) open a 3-game series on Friday. First pitch from Oracle Park is at 10:15 p.m. ET. Let’s check out BetMGM Sportsbook’s MLB odds around the Padres vs Giants Opportunities and place your best bets with our expert MLB tips and predictions.

Season series: Giants lead 6-4

The Padres had Thursday off after losing 5-2 to the Seattle Mariners on Wednesday, meaning they were unable to enjoy a two-game series. They have lost three of their last four games and are a half-game behind the Arizona Diamondbacks for the top NL Wild Card spot.

The Giants are fresh off a 2-1 series loss to the Milwaukee Brewers, losing the finale on Thursday 3-0. Their last 11 games are 4-7.

Expected starters for Padres at Giants

RHP Dylan Cease against RHP Logan Webb

Cease (12-11, 3.71 ERA) is making his 31st start. He has a WHIP of 1.09, 3.2 BB/9 and 10.9 K/9 in 170 innings.

• Last start: Loss, 6 IP, 4 ER, 6 H, 2 BB, 4 K in the 6-3 home loss to the Giants on Saturday; Webb was San Francisco’s starter
• 2024 vs Giants: 0-2, 4.32 ERA (16 2/3 IP, 8 ER), 1.08 WHIP, 9.2 K/9 in 3 starts
• Career against Giants: 2-2, 3.38 ERA (26 2/3 IP, 10 ER), 1.16 WHIP, 9.8 K/9 in 5 starts

Webb (12.9, 3.46 ERA) is making his 31st start. He has a WHIP of 1.23, 2.2 BB/9 and 7.4 K/9 in 189 2/3 innings.

• Last start: Win, 6 IP, 3 ER, 10 H, 2 BB, 3 K Saturday
• 2024 vs. Padres: 1-0, 3.32 ERA (19 IP, 7 ER), 1.53 WHIP, 5.2 K/9 in 3 starts
• Career against Padres: 4-2, 2.70 ERA (76 2/3 IP, 23 ER), 1.19 WHIP, 7.2 K/9 in 13 appearances (12 starts)

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Padres at Giants odds

Provided by BetMGM Sportsbook; visit the USA TODAY Sports Scores and Sports Betting Odds Hub for a complete list of MLB odds. Odds last updated at 11 a.m. ET.

• Moneyline (ML): Padres -115 (bet $115 to win $100) | Giants -105 (bet $105 to win $100)
• Running Line (RL)/Against the Spread (ATS): Padres -1.5 (+155) | Giants +1.5 (-190)
• Over/Under (O/U): 7 (O: -105 | U: -115)

Tips and predictions for the game Padres vs Giants

forecast

Giants 5, Padres 3

Money line

The GIANTS (-105) are 6-2 in Webb’s last 8 starts. They won 2 of 3 games against the Padres last weekend in San Diego. They have limited opponents to 3 or fewer runs in 5 of their last 7 games.

The Padres have lost 2-7 in their last 9 games when allowing 4 or more runs.

The Giants have scored 4 or more points in 6 of their last 10 games.

BETTING GIANTS (-105).

Running Line/Against the Spread

The Giants are 4-1 ATS in their last 5 games. The Padres are 4-9 ATS in their last 13 games.

The Padres are the road favorites at 14-17 ATS.

But if you like the Giants +1.5, the -190 odds aren’t for you. At -105 odds, you should go with the ML.

HAPPEN.

Over/Under

In six of ten games between the two teams there were more than 7 runs in total.

In seven of the Giants’ last 11 games, a total of at least 7 runs have been scored. In Webb’s last 4 starts, a total of 7 or more runs have been scored.

Nine of the Padres’ last eleven games have had a total score of 7 or more.

Bet over 7 (-105).

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