The Cleveland Guardian (90-65) and the St. Louis Cardinals (77-77) played the middle game of a 3-game interleague series on Saturday. First pitch from Busch Stadium is scheduled for 7:15 p.m. ET. Let’s check out BetMGM Sportsbook’s MLB odds around the Guardians vs Cardinals Opportunities and place your best bets with our expert MLB tips and predictions.

Season series: Guardians lead 1-0

The Guardians secured a postseason berth with a win over the Minnesota Twins on Thursday afternoon. Cleveland kept its foot on the gas on Friday, winning the opening game of the interleague series 5-1 as a slight underdog (+102) while the under (8) swept the field.

The Cardinals slipped to .500 with Friday’s loss and are now just 3-5 in their last 8 games. The under has won 5 of their last 6 games while the overall is a low 11-3-1 in their last 15 games. The Cards are out of the postseason race with Friday’s loss.

In interleague play, Cleveland is just 4-6 in its last 10 games against the National League, while it is just 2-5 in its last 7 road games against NL teams. The Under is also 5-0-1 in its last 6 interleague games.

St. Louis has lost 5 straight interleague games and is just 1-6 in their last 7 games against the AL. The Under team has a record of 4-2-1 in their last 7 games against American League opponents.

Guardians at the Cardinals: expected starters

LHP Matthew Boyd against RHP Miles Mikolas

Boyd (2-1, 2.52 ERA) is making his 8th start. He has a WHIP of 1.07, 2.5 BB/9 and 10.1 K/9 in 35 2/3 IP.

• Last start: No decision, 2 2/3 IP, 3 R (2 ER), 5 H, 3 BB, 5 K in the 4-3 home win against the Minnesota Twins on Monday
• 2024 Road Splits: 1-0, 2.87 ERA, 15 2/3 IP, 5 ER, 3 HR, 1.21 WHIP, .213 opposing batting average (OBA), 6 BB, 17 K in 3 starts
• Career vs. Cardinals: 1-0, 1.38 ERA (13 IP, 2 ER), 2 solo HR, 1 BB, 17 K, 0.54 WHIP, 11.8 K/9 in 2 starts

Mikolas (8-11, 5.49 ERA) makes his 31st start. He has a WHIP of 1.29, 1.3 BB/9 and 6.4 K/9 in 160 2/3 IP.

• Last start: No decision, 5 IP, 2 ER, 3 H, 0 BB, 4 K in 3-2 road loss to Toronto Blue Jays last Sunday
• 2024 Home Splits: 1-6, 6.54 ERA, 74 1/3 IP, 54 ER, 14 HR, 1.35 WHIP, .289 OBA, 12 BB, 52 K in 14 starts
• Last 7 games: 0-2, 6.96 ERA, 32 1/3 IP, 25 ER, 2 BB, 28 K, 1.36 WHIP
• Career vs. Guardians: Loss, 7 IP, 2 ER, 5 H, 2 BB, 6 K in 1 start, a 2-0 road loss on August 2, 2014

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Guardians at Cardinals odds

Provided by BetMGM Sportsbook; visit the USA TODAY Sports Scores and Sports Betting Odds Hub for a complete list of MLB odds. Odds last updated at 12:40 p.m. ET.

• Money line: Guardians -135 (bet $135 to win $100) | Cardinals +115 (bet $100 to win $115)
• Running Line (RL)/Against the Spread (ATS): Guardians -1.5 (+135) | Cardinals +1.5 (-160)
• Over/Under (O/U): 8 (O: -105 | U: -115)

Tips and predictions for Guardians at Cardinals

forecast

Guardians 5, Cardinals 2

Money line

The GUARDIAN (-135) are worth a look as moderate favorites behind the left-hander.

The Cardinals (+115) have a respectable 22-19 record against LHP this season, but the problem is Mikolas. St. Louis is 1-3 in their last 4 games and 1-3 in their previous 4 home games as well.

The Cards also have a record of just 3-5 in their last 8 games and 1-4 in their last 5 interleague contests at Busch Stadium.

Running Line/Against the Spread

The GUARDIAN -1.5 (+135) are worth playing cautiously on the run line if you’re feeling a little more adventurous. More risk means more reward. Cleveland has won 6 of its last 7 games, although 3 of its last 4 wins have come by a single run difference.

As favorites, the Guardians are 2-4 in their last 6 games on the run line, so be careful.

Over/Under

Under 8 years (-115) is the slope, but as with the running line above, play this slightly with a Half-unit game maximum.

With the Cardinals, Under is on a 5-1 run in his last six games and has a record of 11-3-1 in his previous 15 meetings.

As for the Guardians, the under record is 15-2-3 in their last 20 games, while they have a record of just 8-1-2 in their last 11 away games.

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