The Minnesota Twins (79-70) and the Cleveland Guardian (86-64) open a 4-game series on Monday (ESPN+). First pitch from Progressive Field is scheduled for 6:40 p.m. ET. Let’s check out BetMGM Sportsbook’s MLB odds for the Twins vs. Guardians Opportunities and place your best bets with our expert MLB tips and predictions.

Season series: Guardians lead 7-2

The Twins saved the series finale against the Cincinnati Reds on Sunday, winning 9-2 as a moderate favorite (-166) because the over (9) was cashed. Minnesota has won 3 of its last 5 games and cashed the over in all 5 games.

The Guardians tied the 4-game series against the Tampa Bay Rays on Sunday, winning 2-0 thanks to RHP Ben Lively. The Under scored in all 4 games of the series at home, with Cleveland scoring an average of 2.8 runs per game (RPG) on offense while allowing just 2.3 RPG.

Cleveland has won 5 of their last 7 games and is 5-3 in their last 8 games played at Progressive Field. The under record in their last 15 games is also 12-1-2.

These teams met in Cleveland from May 17-19. The Guardians won three games, defeating the Twins 19-8, while the underdogs scored in two of the three games.

Twins at the Guardians – expected starters

RHP Pablo Lopez against LHP Matthew Boyd

Lopez (15-8, 3.88 ERA) is making his 30th start. He has a WHIP of 1.13, 1.9 BB/9 and 9.7 K/9 in 169 1/3 IP.

• Last start: Win, 7 IP, 4 R (0 ER), 8 H (1 HR), 1 BB, 10 K in the 10-5 home win against the Los Angeles Angels last Tuesday
• 2024 Road Splits: 8-4, 4.11 ERA, 87 2/3 IP, 40 ER, 14 HR, 1.11 WHIP, .222 opposing batting average (OBA), 24 BB, 100 K in 15 starts
• Last 7 games: 5-1, 1.79 ERA, 45 1/3 IP, 9 ER, 7 BB, 41 K, 1.13 WHIP
• Career vs. Guardians: 2-2, 3.64 ERA, 29 2/3 IP, 12 ER, 32 H, 10 BB, 21 K in 5 starts

Boyd (2-1, 2.18 ERA) is making his 7th start. He has a WHIP of 0.91, 1.9 BB/9 and 9.6 K/9 in 33 IP.

• Last start: No decision, 4 1/3 IP, 4 R (1 ER), 6 H, 2 BB, 9 K in the 6-4 road win against Chicago White Sox on Wednesday
• 2024 Home Splits: 1-1, 1.56 ERA, 17 1/3 IP, 3 ER, 0 HR, 0.63 WHIP, .167 OBA, 1 BB, 18 K in 3 starts
• Career vs. Twins: 9-8, 4.62 ERA, 132 1/3 IP, 68 ER, 40 BB, 134 K, 1.10 WHIP in 23 starts (1 CG)

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Twins in Guardians odds

Provided by BetMGM Sportsbook; visit the USA TODAY Sports Scores and Sports Betting Odds Hub for a complete list of MLB odds. Odds last updated at 6:33 a.m. ET.

• Moneyline (ML): Twins -115 (bet $115 to win $100) | Guardians -105 (bet $105 to win $100)
• Running Line (RL)/Against the Spread (ATS): Gemini -1.5 (+150) | Guardian +1.5 (-185)
• Over/Under (O/U): 7.5 (O: -125 | U: -105)

Tips and predictions for the Twins at the Guardians

forecast

Gemini 4, Guardian 2

Money line

The TWINS (-115) are a solid bet as slight favorites to start this series.

Lopez has been on a tear lately, going 5-1 with a 1.79 ERA in his last 7 starts. It won’t be easy, as left-handed Boyd has also pitched well since his team debut. It will be tough, but Minnesota is a strong option to start off on the right foot.

Running Line/Against the Spread

If you are a little more adventurous, play the TWINS -1.5 (+150) on the run line and not on the money line.

Minnesota has only three wins in its last nine games, but it has won by two or more runs in each of those victories, so if you want the Twins to win, you’d also want them to impress at the run line.

Over/Under

UNDER 7.5 (-105) is a great play in this AL Central Division showdown.

The under is 3-1-1 in their last 5 meetings. While the over has scored at a 5-0 pace on the Twins, the total on the Guardians has been at an insane 12-1-2 pace in their last 15 games.

The under record in Boyd’s last four starts is also 3-1, while the total in Lopez’s last four appearances is a low 2-1-1.

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