INGLEWOOD, Calif. – Wide receiver Rashee Rice left the Kansas City Chiefs’ game against the Los Angeles Chargers with a knee injury in the first quarter and will not return.

Rice injured his right knee after colliding with quarterback Patrick Mahomes while trying to recover a Chargers fumble during an interception return. Both of Rice’s knees were hit in his collision with Mahomes, and the receiver’s right knee appeared to hyperextend.

He was helped off the field and his knee was examined by medical staff on the sideline before being taken to the locker room in a motorized cart.

Rice led the league with 24 catches in Week 4 and was second with 288 yards.

Mahomes threw down Travis Kelce at midfield on the Chiefs’ second drive, and Chargers cornerback Kristian Fulton returned his interception 29 yards with 6:06 to play. Rice caught Fulton from behind at the Chiefs 20 and knocked the ball free for a fumble, but Mahomes hit Rice’s legs as the star quarterback ducked to attempt a tackle on Fulton.

Chiefs center Creed Humphrey recovered the fumble, but video review allowed the Chargers to keep the ball.

Rice is awaiting trial on multiple charges after he allegedly caused a high-speed crash involving multiple cars on a Texas highway last March.

The Associated Press contributed to this report.