The Arizona Cardinals host the Detroit Lions in an NFC showdown on Sunday afternoon. The Cardinals (1-1) defeated the Rams 41-10 in a dominating performance, while the Lions (1-1) lost 20-16 at home to the Buccaneers. Detroit has a 4-0-1 record in their last five meetings, including a 30-12 victory in the last meeting in 2021.

Kickoff at State Farm Stadium is set for 4:25 p.m. ET. Detroit is a 3-point favorite in the latest Cardinals vs. Lions odds, while the over/under total is 51.5. The Lions are -153 moneyline favorites (risk $153, win $100). Before you pick Detroit vs. Arizona, you MUST check out the NFL projections from the SportsLine Projection Model.

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