Veteran nose tackle Michael Pierce, who practiced in full on Friday but was downgraded to doubtful yesterday with a shoulder injury, is inactive for the Ravens, leaving them with just four interior defenders available against the Buffalo Bills.

Nnamdi Madubuike, Travis Jones, Broderick Washington and Brent Urban are the team’s only active defensive linemen. The Ravens could move one of their outside linebackers inside if needed, but it’s still a situation to keep an eye on, especially considering Buffalo uses six offensive linebackers at times to support solid play.

Ravens left guard Andrew Vorhees is also inactive for the Ravens. An ankle injury made him questionable for the game, but he practiced on the field before the game in front of two members of the athletic training staff. With Vorhees sidelined, the Ravens could move right tackle Patrick Mekari to left guard and then use rookie second-round pick Roger Rosengarten at right tackle.

Also inactive for the Ravens: wide receiver Devontez Walker, center Nick Samac and safety Beau Brade.

The Ravens’ third-round rookie outside linebacker Adisa Isaac, fourth-round rookie cornerback TJ Tampa and second-year guard Malaesala Aumavae-Laulu are active for the first time this season. All three would be making their NFL debuts entering the game.