The San Francisco 49ers (1-2) are the favorites (-10.5) according to bookmakers ahead of their game against the New England Patriots (1-2), which will be broadcast on September 29, 2024 at 4:05 p.m. ET on FOX . The matchup has an over/under of 40.5 points.

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49ers vs Patriots Prediction and Picks

• Choose ATS: Choose Em
• Select organizational unit: Under (40.5)
• Forecast: 49ers 25 – Patriots 15

Here’s how to watch San Francisco vs. New England

• Play date: Sunday, September 29, 2024
• Time: 4:05 p.m. ET
• Venue: Levi’s Stadium
• Location: Santa Clara, California
• TV: Watch on FOX
• Live boxscore: FOX Sports

Picks from FOX Sports Betting Analyst Chris Fallica:

Last week’s loss at the Rams was terrible and inexcusable for the Niners, despite all the injuries. Blowing a two-TD lead against a team with as many key injuries as the Rams just can’t happen. Luckily, the Niners get one of the worst teams in the league to start at home. The Patriots’ O-line against the Jets was just awful and I can’t imagine it getting much better here. SF gets up early and scores a stunning victory.

PICK: 49ers (-10.5) win by more than 10.5 points

Read more NFL predictions for this week

Current matches between 49ers and Patriots

• In the last four meetings, New England has won three times against San Francisco.
• San Francisco has outscored New England by 29 points in its last four meetings.

San Francisco betting information

• This year, San Francisco has a win against the spread.
• At this year’s San Francisco Games, the over/under number was exceeded on three occasions (66.7%).
• When playing as moneyline favorites, the 49ers are 1-2 and win 33.3% of the time.
• Looking at the money line for this contest, the 49ers’ implied win probability is 85.7%.

49ers stats

San Francisco’s key players

attack

• Brock Purdy ranks third in the NFL with 842 passing yards in three games this year, an average of 280.7 per game with a 72.6% completion rate, and four touchdowns (10th in the NFL) against one interception.
• He has racked up 64 rushing yards (21.3 per game) without a touchdown on the ground.
• Jordan Mason’s rushing statline this season includes 324 yards (second in the NFL) and two touchdowns. He averages 108.0 yards per game and 4.8 yards per attempt (16th in the NFL).
• In the passing game, Jauan Jennings posted 276 receiving yards (fifth in the NFL) and three touchdowns (first in the NFL) after catching 18 balls (10th in the NFL) on 21 targets. He is averaging 92.0 yards and 6.0 receptions per game in three games.
• Deebo Samuel has 13 receptions for 164 yards and zero touchdowns. He was targeted 19 times in the passing game and averaged 6.5 receptions and 82.0 yards in two games played.

defense

• On the defensive side, Fred Warner has 20 tackles, 1.0 TFL, one sack and one interception in 2024. He leads the 49ers in total tackles.
• Nick Bosa has nine tackles, 3.0 TFL and two sacks.
• This season, Isaac Yiadom has made 13 tackles.
• So far this season, Charvarius Ward has 13 tackles.

New England Betting Information

• New England has a record of 2-1-0 against the spread this season.
• Games involving New England have reached the end once this year.
• This season, the Patriots have won one of the three games in which they were the underdog.
• Based on the money line implied probability, the Patriots have an 18.5% chance of winning this game.

Patriots stats

New England’s key players

attack

• Rhamondre Stevenson is averaging 74.7 rushing yards per game this year (224 total yards) while scoring two rushing touchdowns.
• Jacoby Brissett has 368 passing yards, one touchdown and zero interceptions. His completion rate is 60.9% and he averages 122.7 yards per game and 5.3 per attempt.
• He also added 38 rushing yards (third on the Patriots) with zero touchdowns on the ground (averaging 12.7 yards per game and 4.2 per carry).
• So far this season, Antonio Gibson has accumulated 143 rushing yards (second on the Patriots) in three games but has not scored a rushing touchdown. He averages 47.7 yards per game and 6.2 yards per attempt (third in the NFL).
• Hunter Henry has 12 catches for 136 yards without a receiving touchdown. He is averaging 4.0 yards per game through three games and has been targeted 18 times.

defense

• Keion White’s 2024 performance includes 17 tackles, 3.0 TFL and four sacks in three games. He is second on the Patriots in tackles.
• Kyle Dugger has 16 tackles, 3.0 TFL and one sack. He is fourth on the Patriots in tackles.
• Jonathan Jones has 18 tackles in the 2024 season. He leads the Patriots in tackles.
• Jahlani Tavai has 17 tackles, 2.0 TFL and one pass defensed.

FOX Sports created this story using technology and data from Sportradar provided by Data Skrive.

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