Before they appeared as Colin and Penelope in BridgertonNicola Coughlan and Luke Newton didn’t take a chemistry test, but they spent the years leading up to Season 3 building their friendship off-screen, so their on-screen chemistry was incredibly strong.
3.
Scott Patterson and Lauren Graham did not have a chemistry test before they were cast as Luke and Lorelai in The Gilmore Girls. They first met at a hotel in Canada and the cast had dinner together before filming the pilot episode.
4.
In the meantime, Milo Ventimiglia was given the role of Jess Mariano in “Gilmore Girls” after an audition and without a chemistry test alongside Alexis Bledel.
5.
Due to the COVID-19 pandemic, Emma D’Arcy and Olivia Cooke did not take a chemistry test together before being cast for the roles of Rhaenyra Targaryen and Alicent Hightower in House of the Dragon.
6.
Pedro Pascal and Bella Ramsey had never spoken to each other before they were officially cast as Joel Miller and Ellie Williams in The Last of UsIn fact, they first met via Zoom during the show’s sexual harassment prevention training.
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During the audition for Bellamy Blake on The 100Bob Morley said he never did a chemistry read with anyone, including Eliza Taylor, who played the role of Clarke Griffin. In fact, he got the role within 10 days.
8.
When Dan Levy was looking for a cast for David’s lover, Schitt’s CreekHe hired Noah Reid without taking a chemistry test with him. The first time they read together was during the cast review for Patrick’s first episode in Season 3.
9.
Quinta Brunson actually sent Tyler James Williams a direct message and asked him to play the lead role in Abbott Elementary School as Gregory. Tyler revealed to the Hollywood Reporter that Quinta sent him the script after exchanging messages and he accepted, so there was no formal chemistry reading between the two.
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Although Linda Cardellini and Christina Applegate are both experienced actresses, they had Dead to meAlthough there was no traditional reading about their chemistry, both had lunch with creator Liz Feldman before filming, where she really noticed how well the two fit together.
11.
Zach Braff first met Donald Faison at the first reading for ScrubsEven though they had to play best friends JD and Turk, they did not get to know each other during the audition.
12.
Katherine Barrell and Dom Provost-Chalkley first met when Kat was on the set of Wynonna Earp for filming the second episode, in which Waverly meets Nicole.
13.
Freddy Carter and Amita Suman did not have a chemistry test before they went to Shadows and Bones together as Kaz Brekker and Inej Ghafa. Amita told Collider: “Freddy and I didn’t do any chemistry tests. But when he walked through the door, I knew that, at least in my eyes, this was the perfect Kaz.”
14.
When Stefania Spampinato came along Station 19 after her role as Carina DeLuca in Grey’s Anatomyshe and Danielle Savre had never met before and had never done a chemistry reading. The first time they met was during the reading for Stefania’s first Station 19 Consequence.
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And finally, Emily Bett Rickards was originally only supposed to appear in one episode of Arrow as Felicity Smoak. She had no chemistry reading with Stephen Amell before filming and their chemistry ultimately changed the course of the series.
